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Monday, August 16, 2010

PROCEDURE FOR CLEANING OF REACTION VESSEL

1.0 PURPOSE
This SOP describes the cleaning operation of reaction vessel to ensure that the vessel is free from previous batch material
2.0 RESPONSIBILITY
Operators and chargers are responsible for the cleaning of the reactor from the inner side. External cleaning is a continuous routine process.
3.0 PROCEDURE
a) Ensure that previous batch material is completely removed from the reactor.
b) Open manhole cover and close the bottom discharge valve.
c) Flush the reactor with water using spray nozzle .also wash the top dish with the help of spay nozzle.
d) Open bottom dish valve and drain the spray washings into the affluent tray .
e) Close the bottom valve ,fill the reactor with water ,stir for 10 min. and drain out the water.
f) Inspect and ensure that the reactor is clean.
g) If required repeat the above operations using detergents.
h) When the previous material is insoluble in water ,clean the reactor with solvent in which it is soluble and then with water.
i) Clean the manhole cover properly and dry it with sponge.
j) Dry the reactor by circulating steam in the jacket and by applying mild vacuum.
k) Ensure that the reactor is dry and fix the label “CLEAN” on the reactor.
4.0 PERIODICITY
The cleaning operation should be carried out after every batch.
5.0 FORMAT
Equipment cleaning format should be used.

3 comments:

pharmanaukri said...

Ya fine what you guide.
here you discussed about reactors only.But many pharmaceuticals and biotech industries has lot of vessels for preparation of buffers and reagents which will they use for further process.

If possible let you post the above details.

Mahender.Nagaraju Hyderabad India.
(Biotech Professional)&
Executive Director of www.pharmanaukri.info

kurdo said...

Good idea

kurdo said...

can we follow this for IBC